Here, we show that functionalization of the 4-arylidene position of the fluorescent curcumin scaffold with an aryl nitrogen mustard provides a stable Hck inhibitor (Kd = 50 ± 10 nM). The mustard curcumin derivative preferentially interacts with the inactive conformation of Hck, similar to type-II kinase inhibitors that are less https://bahis-siteleri-deneme-bonusu.birderswiki.com/1198574/Факт_О_bçlnk_păķtłęri_что_никто_не_говорит